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Brief facts about 2me2:

2-Methoxyestradiol is a natural metabolite of estradiol and 2-hydroxyestradiol. It is specifically the 2-methyl ether of 2-hydroxyestradiol. 2-Methoxyestradiol prevents the formation of new blood vessels that tumors need in order to grow, hence it is an angiogenesis inhibitor. It also acts as a vasodilator and induces apoptosis in some cancer cell lines. 2-Methoxyestradiol is derived from estradiol, although it interacts poorly with the estrogen receptors. However, it retains activity as a high-affinity agonist of the G protein-coupled estrogen receptor.

2-Methoxyestriol - 2-Methoxyestriol is an endogenous estrogen metabolite. It is specifically a metabolite of estriol and 2-hydroxyestriol. It has negligible affinity for the estrogen receptors and no estrogenic activity.

2-Methoxyestrone - 2-Methoxyestrone is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 2-hydroxyestrone.

4-Methoxyestradiol - 4-Methoxyestradiol is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estradiol that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestradiol. It has estrogenic activity similarly to estrone and 4-hydroxyestrone.

4-Methoxyestrone - 4-Methoxyestrone is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestrone. It has estrogenic activity similarly to estrone and 4-hydroxyestrone.

MP-2001 - MP-2001, also known as 2,3,4-trimethoxyestra-1,3,5-trien-17β-ol or 2,4-dimethoxyestradiol 3-methyl ether, is a steroid and derivative of estradiol that was described in 1966 and is devoid of estrogenic activity but produces potent analgesic effects in animals. It was never marketed.

Microtubule inhibitors

Mitotic inhibitors

Angiogenesis inhibitors

Hypolipidemic agents

Human metabolites

Antineoplastic drugs

Ethers